与输注ε-氨基己酸相关的非炎性大疱

Noninflammatory bullae associated with epsilon-aminocaproic acid infusion.

作者信息

Brooke C P, Spiers E M, Omura E F

机构信息

Department of Dermatology, University of Alabama, Birmingham.

出版信息

J Am Acad Dermatol. 1992 Nov;27(5 Pt 2):880-2. doi: 10.1016/0190-9622(92)70272-h.

DOI:10.1016/0190-9622(92)70272-h

PMID:1469150

Abstract

Three patients who had cardiac surgery developed a transient, noninflammatory subepidermal bullous eruption on the legs after epsilon-aminocaproic acid infusion. Fibrin thrombi were demonstrated in papillary dermal vessels. The use of epsilon-aminocaproic acid as an antifibrinolytic agent may predispose patients to cutaneous vascular thromboses.

摘要

三名接受心脏手术的患者在输注ε-氨基己酸后，腿部出现了短暂的、非炎症性的表皮下大疱性皮疹。在真皮乳头层血管中发现了纤维蛋白血栓。使用ε-氨基己酸作为抗纤维蛋白溶解剂可能使患者易患皮肤血管血栓形成。