1型人类嗜T淋巴细胞病毒携带者中的渐进性坏死性黄色肉芽肿。

Necrobiotic xanthogranuloma in a human T-lymphotropic virus type 1 carrier.

作者信息

Nishimura M, Takano-Nishimura Y, Yano I, Hayashi N, Toshitani S

机构信息

Department of Clinical Genetics, Kyushu University, Beppu, Japan.

出版信息

J Am Acad Dermatol. 1992 Nov;27(5 Pt 2):886-9. doi: 10.1016/0190-9622(92)70274-j.

DOI:10.1016/0190-9622(92)70274-j

PMID:1469152

Abstract

A 67-year-old man who had necrobiotic xanthogranuloma associated with paraproteinemia is described. He was a human T-lymphotropic virus type 1 (HTLV-1) carrier who had a high titer of circulating anti-HTLV-1 antibodies and neurologic abnormalities that suggested HTLV-1-associated myelopathy. The patient's necrobiotic xanthogranuloma and neurologic symptoms improved after he received four 5-day courses of melphalan, 2 mg/day, and prednisolone, 20 mg/day, at 4-week intervals.

摘要

本文描述了一名67岁患有与副蛋白血症相关的坏死性黄色肉芽肿的男性患者。他是一名1型人类嗜T淋巴细胞病毒（HTLV-1）携带者，循环抗HTLV-1抗体滴度高，并有提示HTLV-1相关脊髓病的神经学异常。该患者在接受了四个疗程、为期5天、每天2毫克美法仑和每天20毫克泼尼松龙、间隔4周的治疗后，其坏死性黄色肉芽肿和神经症状有所改善。