El-Domyati Moetaz M, Attia Sameh K, Saleh Fatma Y, Ahmad Hesham M, Gasparro Frances P, Uitto Jouni J
Department of Dermatology, Faculty of Medicine, Al-Minya University, Cairo, Egypt.
Eur J Dermatol. 2003 Sep-Oct;13(5):433-8.
The tumour suppressor protein p53 is a phosphoprotein that is activated by DNA damage. It is involved in the decision whether the cells should stop replication and proceed to repair their DNA, or to die by apoptosis. In the present study, we evaluate the effect of some treatment modalities on the expression of p53 in facial skin. Biopsy specimens were obtained from the facial skin of 20 patients before and after treatment using topical tretinoin (11 cases), TCA chemical peeling (5 cases) and dermabrasion (4 cases). Biopsy specimens were also obtained from 12 control subjects representing the same age groups of the patients. Topical tretinoin therapy was found to induce a significant decrease in the expression of p53 up to 6 months of therapy followed by a significant increase after 10 months of therapy. On the contrary, superficial TCA peeling did not induce any statistically significant change in the expression of p53. On the other hand dermabrasion was found to induce a significant decrease in the level of expression of p53 in biopsies obtained after complete re-epithelialization followed by a significant increase. These changes in the expression of p53 may play a role in mediating the effects of such treatment modalities on the epidermis, as well as prevention of actinic neoplasia by adjusting any disturbance in the proliferation/apoptosis balance observed in photoaged facial skin.
肿瘤抑制蛋白p53是一种受DNA损伤激活的磷蛋白。它参与决定细胞是应停止复制并着手修复其DNA，还是通过凋亡死亡。在本研究中，我们评估了某些治疗方式对面部皮肤中p53表达的影响。使用外用维甲酸（11例）、三氯乙酸化学剥脱术（5例）和磨皮术（4例）治疗前后，从20例患者的面部皮肤获取活检标本。还从12名代表患者同一年龄组的对照受试者获取活检标本。发现外用维甲酸治疗在治疗6个月内可使p53表达显著降低，而在治疗10个月后则显著升高。相反，浅表三氯乙酸剥脱术未引起p53表达的任何统计学显著变化。另一方面，发现磨皮术在完全重新上皮化后获取的活检标本中可使p53表达水平显著降低，随后显著升高。p53表达的这些变化可能在介导此类治疗方式对表皮的作用以及通过调节光老化面部皮肤中观察到的增殖/凋亡平衡的任何紊乱来预防光化性肿瘤形成中发挥作用。
