Scheibe Paul O
Ixzar, Arroyo Grande, CA 93420, USA.
Nucl Med Biol. 2003 Nov;30(8):827-32. doi: 10.1016/s0969-8051(03)00118-5.
Models provide a means to represent our understanding of the interaction among the components of a system. Individual instantiations of a system are captured by allowing the model to have parameters that may be different for each instantiation. Included in the model is a representation of the means to observe certain aspects of a system. Given the observations, successful estimation of the parameters requires that the parameters be identifiable. This is an important consideration for potential use of the model in diagnostic medicine or analysis and planning of experiments. Models considered here are typical of those used to describe flows and concentrations associated with ligand-receptor interactions.
模型提供了一种手段来表示我们对系统各组件之间相互作用的理解。通过允许模型具有针对每个实例可能不同的参数，可以捕获系统的各个实例。模型中包含对观察系统某些方面的手段的表示。给定这些观察结果，要成功估计参数就要求参数是可识别的。这对于该模型在诊断医学或实验分析与规划中的潜在应用而言是一个重要的考虑因素。这里所考虑的模型是用于描述与配体 - 受体相互作用相关的流量和浓度的典型模型。
