Kim Y S
Gastrointestinal Research Laboratory (151M2), VA Medical Center, San Francisco, California.
J Cell Biochem Suppl. 1992;16G:91-6. doi: 10.1002/jcb.240501117.
Considerable alteration of cellular carbohydrates such as glycolipids and glycoproteins occurs in colonic neoplasia. Some of these changes are also observed at certain embryonic stages of differentiation and are, therefore, considered onco-developmental changes. In colon cancer cells, many of the phenotypic markers for malignancy have been found on carbohydrate moieties, and some have been found on the peptide portion of mucin glycoproteins. The changes in carbohydrate antigens include altered expression of core region carbohydrates, extension of backbone structures and modification of peripheral carbohydrate structures that may arise due to abnormal glycosylation processes. Altered glycosylation may also result in the exposure of the peptide moiety of the mucin glycoprotein. Therefore, these altered mucin glycoprotein structures may serve as tumor markers. However, it remains to be determined whether they will be useful as intermediate endpoint markers.
在结肠肿瘤形成过程中，细胞碳水化合物如糖脂和糖蛋白会发生显著改变。其中一些变化在特定的胚胎分化阶段也能观察到，因此被认为是肿瘤发育相关的变化。在结肠癌细胞中，许多恶性表型标志物已在碳水化合物部分被发现，还有一些在粘蛋白糖蛋白的肽段部分被发现。碳水化合物抗原的变化包括核心区域碳水化合物表达改变、主链结构延长以及可能因异常糖基化过程而导致的外周碳水化合物结构修饰。糖基化改变还可能导致粘蛋白糖蛋白肽段部分的暴露。因此，这些改变的粘蛋白糖蛋白结构可能作为肿瘤标志物。然而，它们是否能作为中间终点标志物还有待确定。
