Moulin B, Ollier J, Olmer M
Service de Néphrologie, Hôpital de la Conception, CHU Marseille.
Nephrologie. 1992;13(5):193-9.
Both increased synthesis and decreased catabolism of lipoproteins may account for the severe hyperlipidemia which frequently occurs in patients with the nephrotic syndrome (NS). Nevertheless the complex relation between hyperlipidemia and proteinuria remains unclear and still debated. Increased levels of serum total cholesterol, of low-density lipoprotein and of apolipoprotein B are the most characteristic reported abnormalities placing these patients at high risks for atherosclerotic vascular disease. Moreover recent experiments have suggested that hyperlipidemia may also play a role in the progression of renal disease. Thus the reasons for using hypolipemic treatment are now growing in number and recent trials with lipid lowering medication have been successful without major side effects.
脂蛋白合成增加和分解代谢减少都可能是肾病综合征（NS）患者经常出现严重高脂血症的原因。然而，高脂血症与蛋白尿之间的复杂关系仍不清楚，仍存在争议。血清总胆固醇、低密度脂蛋白和载脂蛋白B水平升高是最具特征性的报告异常，使这些患者处于动脉粥样硬化性血管疾病的高风险中。此外，最近的实验表明，高脂血症也可能在肾脏疾病的进展中起作用。因此，使用降血脂治疗的理由现在越来越多，最近使用降脂药物的试验取得了成功，且没有重大副作用。
