Binding of imidazole-derived nucleosides to a CG base pair.
作者信息
Purwanto Maria G M, Weisz Klaus
机构信息
Institut für Chemie und Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Soldmannstrasse 16, D-17489 Greifswald, Germany.
出版信息
J Org Chem. 2004 Jan 9;69(1):195-7. doi: 10.1021/jo035597q.
PMID:14703398
Abstract
Novel imidazole nucleosides with substituents of different flexibility were studied for their binding to a CG Watson-Crick base pair by (1)H NMR spectroscopy in an aprotic solvent. Thermodynamic data as determined by titration experiments at different temperatures reveal the influence of the substituent on the enthalpy and entropy of complex formation and thus on the strength of binding.
摘要
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