Xu Li, Meng Huan-xin, Chen Zhi-bin
Department of Periodontology, Peking University School of Stomatology, Beijing 100081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2003 Nov;38(6):405-7.
To investigate the relationship between smoking and gingival crevicular fluid volume (GCF), level of elastase (EA) in 37 severe periodontitis patients before and after 1 month periodontal initial treatment.
The GCF samples were collected from 122 sites in 22 heavy smokers (>or= 20 cigarettes/day) and 90 sites in 15 non-smokers before and after 1 month periodontal initial treatment. There is no difference (P > 0.05) on pocket depth between smoking sites (5.6 +/- 1.2) mm and non-smoking sites (5.4 +/- 1.2) mm at baseline. The volume of each GCF sample was measured by Periotron 6000 and the elastase in GCF were determined by substrate (meosuc-als-als-pro-val-NA) method.
After non-surgical treatment both GCF volume and elastase level were significantly decreased (P < 0.001) in both smokers and non-smokers. But the decrease of GCF volume (91 sites, 74.6%) and elastase level (70 sites, 76.1%) in smokers were significant lower (P < 0.01) than non-smokers (GCF, 88 sites, 97.8%; EA, 56 sites, 93.3%).
These findings suggest that smoking has effect on gingival crevicular fluid volume and elastase level of patients with periodontitis.
探讨37例重度牙周炎患者在牙周初始治疗1个月前后吸烟与龈沟液量（GCF）、弹性蛋白酶（EA）水平之间的关系。
在牙周初始治疗1个月前后，从22名重度吸烟者（≥20支/天）的122个位点和15名非吸烟者的90个位点采集龈沟液样本。基线时，吸烟位点（5.6±1.2）mm与非吸烟位点（5.4±1.2）mm的牙周袋深度无差异（P>0.05）。每个龈沟液样本的量用Periotron 6000测量，龈沟液中的弹性蛋白酶用底物（meosuc-als-als-pro-val-NA）法测定。
非手术治疗后，吸烟者和非吸烟者的龈沟液量和弹性蛋白酶水平均显著降低（P<0.001）。但吸烟者龈沟液量（91个位点，74.6%）和弹性蛋白酶水平（70个位点，76.1%）的降低幅度显著低于非吸烟者（龈沟液，88个位点，97.8%；弹性蛋白酶，56个位点，93.3%）（P<0.01）。
这些发现表明吸烟对牙周炎患者的龈沟液量和弹性蛋白酶水平有影响。
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