Hirst G R, Karandikar S S, Brown G, Slowey H, Beynon J
Singleton Hospital, Sketty Lane, Swansea, SA2 8QA, UK.
Int J Colorectal Dis. 2004 May;19(3):281-2. doi: 10.1007/s00384-003-0564-2. Epub 2003 Dec 24.
Muscle relaxation is administered to patients undergoing laparotomy for colonic surgery. At the end of the procedure, relaxation needs to be reversed to facilitate extubation. This may be achieved by administering anticholinesterases such as neostigmine.
We present a case of colonic anastomotic dehiscence in the immediate postoperative period following the use of neostigmine to reverse intra-operative muscle relaxation.
Neostigmine is frequently used to reverse muscle relaxation at the end of colonic surgery. However, the drug should be used with caution as it has been implicated as a cause of early anastomotic disruption.