Ogino Takashi
Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan.
Gan To Kagaku Ryoho. 2003 Dec;30(13):2030-5.
Proton beam therapy (PBT) makes it possible to deliver a higher concentration of radiation to the tumor by its Bragg-peak, and is easy to utilize due to its identical biological characteristics with X-rays. PBT has a half-century history, and more than 35,000 patients have been reported as having had treatments with proton beams worldwide. The historic change to this therapy occurred in the 1990s, when the Loma Linda University Medical Center began clinical activity as the first hospital in the world to utilize a medically dedicated proton therapy facility. Since then, similar hospital-based medically dedicated facilities have been constructed. Results from around the world have shown the therapeutic superiority of PBT over alternative treatment options for ocular melanoma, skull base sarcoma, head and neck cancer, lung cancer, esophageal cancer, hepatocellular carcinoma, and prostate cancer. PBT is expected to achieve further advancement both clinically and technologically.
质子束疗法（PBT）通过其布拉格峰能够将更高浓度的辐射传递到肿瘤部位，并且由于其与X射线具有相同的生物学特性，易于应用。PBT已有半个世纪的历史，据报道，全球有超过35000名患者接受过质子束治疗。这种疗法的历史性变革发生在20世纪90年代，当时洛马林达大学医学中心作为世界上第一家使用医疗专用质子治疗设施的医院开始了临床活动。从那时起，类似的基于医院的医疗专用设施相继建成。世界各地的结果表明，PBT在治疗眼黑色素瘤、颅底肉瘤、头颈癌、肺癌、食管癌、肝细胞癌和前列腺癌方面比其他治疗选择具有治疗优势。预计PBT在临床和技术方面都将取得进一步进展。
