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用于旋光性、多重散射组织模型的低噪声精密偏振测量的平衡检测。

Balanced detection for low-noise precision polarimetric measurements of optically active, multiply scattering tissue phantoms.

作者信息

Côté D, Vitkin I A

机构信息

Ontario Cancer Institute, Department of Medical Biophysics, University Health Network, University of Toronto, Toronto, Ontario, Canada M5G 2M9.

出版信息

J Biomed Opt. 2004 Jan-Feb;9(1):213-20. doi: 10.1117/1.1629683.

DOI:10.1117/1.1629683
PMID:14715076
Abstract

The use and advantages of balanced detection for making low-noise polarimetric measurements in turbid materials are demonstrated. The technique reduces the intensity noise originating from the laser and, in addition, makes possible a direct measurement of a component of the Stokes vector. When phase-locked detection is used with either amplitude or polarization modulation for polarimetric measurements in turbid media, one can obtain elements of the scattering matrix of very small magnitude. This methodology is used to measure optical activity and surviving linear polarization fractions in clear and turbid media containing glucose at physiologically relevant concentrations. The results are in agreement with Monte Carlo simulations of polarized light propagation in turbid media.

摘要

本文展示了平衡检测在浑浊材料中进行低噪声偏振测量的应用及优势。该技术降低了源自激光的强度噪声,此外,还能直接测量斯托克斯矢量的一个分量。当在浑浊介质中进行偏振测量时,将锁相检测与幅度或偏振调制结合使用,可以获得幅度非常小的散射矩阵元素。这种方法用于测量含有生理相关浓度葡萄糖的透明和浑浊介质中的旋光性和剩余线性偏振分数。结果与浑浊介质中偏振光传播的蒙特卡罗模拟结果一致。

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