Hamajima Nobuyuki, Shibata Atsuko, Katsuda Nobuyuki, Matsuo Keitaro, Ito Hidemi, Saito Toshiko, Tajima Kazuo, Tominaga Suketami
Department of Preventive Medicine / Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan.
Gastric Cancer. 2003;6(4):230-6. doi: 10.1007/s10120-003-0258-z.
A possible association between Helicobacter pylori seropositivity and tumor necrosis factor (TNF) a G-308A has been reported in Korea. The present study examined the associations of H. pylori with functional polymorphisms, TNF-A G-308A, C-857T, and T-1031C and TNF-B A252G in Japanese subjects.
The total of 1374 study subjects included 241 outpatients who participated in an H. pylori eradication program (HPE), 679 first-visit outpatients (FVO) at a regional cancer hospital, and 454 local residents who received a health checkup examination (HCE).
The frequency of the TNF-A -308A allele was only 1.3% of 480 chromosomes in the HPE group, so the FVO and HCE groups were not genotyped for that polymorphism. The genotype frequency of TNF-A C-857T was 69.2% CC, 27.7% CT, and 3.1% TT; that of TNF-A T-1031C was 69.4% TT, 28.1% TC, and 2.5% CC; and that of TNF-B A252G was 36.8% AA, 48.2% AG, and 15.0% GG. TNF-A -857T was tightly linked to TNF-A -1031T and TNF-B 252A. No significant associations between H. pylori seropositivity and polymorphisms of TNF-A C-857T and TNF-B A252G were observed. However, a reduced odds ratio adjusted for sex, age, and recruitment source was observed for TNF-A -1031CC (0.43; 95% confidence interval, 0.20-0.91) relative to TNF-A -1031TT. Subjects with TNF-A -857CC and -1031CC showed the lowest seropositivity (38.2% of 34 participants), while those with TNF-A -857TT and -1031TT showed the highest (66.7% of 42 participants).
This study suggests that the possibly high expression genotype of TNF-A may increase susceptibility to persistent H. pylori infection.A possible association between Helicobacter pylori seropositivity and tumor necrosis factor ( TNF) A G-308A has been reported in Korea. The present study examined the associations of H. pylori with functional polymorphisms, TNF-A G-308A, C-857T, and T-1031C, and TNF-B A252G in Japanese subjects.
在韩国，已报道幽门螺杆菌血清阳性与肿瘤坏死因子（TNF）α G-308A之间可能存在关联。本研究调查了日本受试者中幽门螺杆菌与功能多态性TNF-α G-308A、C-857T、T-1031C以及TNF-β A252G之间的关联。
总共1374名研究对象包括241名参与幽门螺杆菌根除计划（HPE）的门诊患者、679名地区癌症医院的初诊门诊患者（FVO）以及454名接受健康检查的当地居民（HCE）。
在HPE组的480条染色体中，TNF-α -308A等位基因的频率仅为1.3%，因此未对FVO组和HCE组进行该多态性的基因分型。TNF-α C-857T的基因型频率为CC 69.2%、CT 27.7%、TT 3.1%；TNF-α T-1031C的基因型频率为TT 69.4%、TC 28.1%、CC 2.5%；TNF-β A252G的基因型频率为AA 36.8%、AG 48.2%、GG 15.0%。TNF-α -857T与TNF-α -1031T以及TNF-β 252A紧密连锁。未观察到幽门螺杆菌血清阳性与TNF-α C-857T和TNF-β A252G多态性之间存在显著关联。然而，相对于TNF-α -1031TT，在对性别、年龄和招募来源进行校正后，观察到TNF-α -1031CC的优势比降低（0.43；95%置信区间，0.20 - 0.91）。TNF-α -857CC和-1031CC的受试者血清阳性率最低（34名参与者中的38.2%），而TNF-α -857TT和-1031TT的受试者血清阳性率最高（42名参与者中的66.7%）。
本研究表明，TNF-α可能的高表达基因型可能会增加对持续性幽门螺杆菌感染的易感性。在韩国，已报道幽门螺杆菌血清阳性与肿瘤坏死因子（TNF）α G-308A之间可能存在关联。本研究调查了日本受试者中幽门螺杆菌与功能多态性TNF-α G-308A、C-857T、T-1031C以及TNF-β A252G之间的关联。
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