Tao Xia, Liu Gao-lin
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Yao Xue Xue Bao. 2003 Oct;38(10):743-7.
To study the importance of blood pressure variability in organ protection for long-term treatment with fosinopril in-sinoaortic-denervated (SAD) rats.
Fosinopril (15 mg.kg-1.d-1) was given in rat chow for 16 weeks after SAD surgery. Blood pressure variability (BPV) was recorded during 24 h in conscious state. Histopathological changes were evaluated with light microscope and computer-assisted image analysis.
Long-term treatment with fosinopril significantly decreased BPV in SAD rats. The thickness of the left ventricular wall, collagen fraction of the left ventricle and glomerulosclerosis score were all positively related to BPV in untreated and fosinopril-treated SAD rats. Fosinopril markedly prevented the damages of target organs in SAD rats.
Long-term treatment with fosinopril showed obvious organ protection in SAD rats. The decrease in BPV may significantly contribute to organ protection.
研究血压变异性在福辛普利长期治疗去窦弓神经（SAD）大鼠时对器官保护中的重要性。
SAD手术后，在大鼠饲料中加入福辛普利（15毫克·千克-1·天-1），持续16周。在清醒状态下记录24小时内的血压变异性（BPV）。用光学显微镜和计算机辅助图像分析评估组织病理学变化。
福辛普利长期治疗可显著降低SAD大鼠的BPV。在未治疗和福辛普利治疗的SAD大鼠中，左心室壁厚度、左心室胶原分数和肾小球硬化评分均与BPV呈正相关。福辛普利显著预防了SAD大鼠靶器官的损伤。
福辛普利长期治疗对SAD大鼠显示出明显的器官保护作用。BPV的降低可能对器官保护有显著贡献。
