酵母中的端粒位置效应

Telomeric position effect in yeast.

作者信息

Sandell L L, Zakian V A

机构信息

Fred Hutchinson Cancer Research Center, 1124 Columbia St, Seattle, WA 9810, USA.

出版信息

Trends Cell Biol. 1992 Jan;2(1):10-4. doi: 10.1016/0962-8924(92)90138-d.

DOI:10.1016/0962-8924(92)90138-d

PMID:14731632

Abstract

Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.

摘要

端粒是染色体的物理末端。在酵母中，当一个基因位于端粒附近时，其转录会受到抑制。受这种端粒位置效应影响的基因在抑制状态和转录激活状态之间切换，每种状态在许多细胞世代中都是稳定的。端粒位置效应可能为研究其他更复杂生物体中的可遗传基因调控提供一个模型系统。