核糖核酸酶传递的新的神秘生物学信息。

New and cryptic biological messages from RNases.

作者信息

D'Alessio G

机构信息

Department of Organic and Biological Chemistry, University of Naples Federico II, Naples, Italy.

出版信息

Trends Cell Biol. 1993 Apr;3(4):106-9. doi: 10.1016/0962-8924(93)90166-x.

DOI:10.1016/0962-8924(93)90166-x

PMID:14731764

Abstract

RISBASEs are RNases with surprising biological actions, or unexpected physiological roles, in which they act as external factors that influence cell behaviour. There are RISBASEs involved in host defence, angiogenesis and the control of pollen fertility, and RISBASEs with antitumour and antispermatogenic actions. Here, Guiseppe D'Alessio describes these unusual roles for RNases, and speculates about the mechanisms underlying their actions.

摘要

核糖核酸酶基础（RISBASEs）是一类具有惊人生物学作用或意想不到生理功能的核糖核酸酶，它们作为影响细胞行为的外部因素发挥作用。有参与宿主防御、血管生成和花粉育性控制的RISBASEs，以及具有抗肿瘤和抗生精作用的RISBASEs。在此，朱塞佩·达莱西奥描述了核糖核酸酶的这些不同寻常的作用，并推测了其作用背后的机制。