生长因子与细胞外基质之间的协同相互作用。

Collaborative interactions between growth factors and the extracellular matrix.

作者信息

Schubert D

机构信息

The Salk Institute, PO Box 85800, San Diego, CA 92186-5800, USA.

出版信息

Trends Cell Biol. 1992 Mar;2(3):63-6. doi: 10.1016/0962-8924(92)90057-t.

DOI:10.1016/0962-8924(92)90057-t

PMID:14731930

Abstract

The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines possible mechanisms underlying the synergistic interactions of growth factors and the ECM.

摘要

细胞外基质（ECM）成分在调节细胞黏附、增殖和分化方面的作用正受到广泛关注。最近，有一点变得很明显，即某些细胞反应需要ECM成分和可溶性生长因子的共同作用。本文探讨了生长因子与ECM协同相互作用背后的可能机制。