Panayotou G, Waterfield M D
Ludwig Institute for Cancer Research, University College/Middlesex Hospital Branch, 91 Riding House Street, London, UK W1P 8BT.
Trends Cell Biol. 1992 Dec;2(12):358-60. doi: 10.1016/0962-8924(92)90042-l.
Phosphatidylinositol (PI) 3-kinase associates in signal-transducing complexes with activated growth factor receptors and other protein tyrosine kinases. The enzyme may also act downstream of receptors that are not tyrosine kinases in terminally differentiated cells. The recent cloning of the catalytic subunit of PI 3-kinase has revealed a structural similarity to a yeast protein important in vacuolar protein sorting. This finding provides some interesting clues to the function of PI3-kinase in diverse cellular responses.
磷脂酰肌醇（PI）3激酶在信号转导复合物中与活化的生长因子受体及其他蛋白酪氨酸激酶相结合。该酶也可能在终末分化细胞中那些并非酪氨酸激酶的受体下游发挥作用。最近对PI 3激酶催化亚基的克隆揭示了其与酵母中一种在液泡蛋白分选过程中起重要作用的蛋白质在结构上的相似性。这一发现为PI3激酶在多种细胞反应中的功能提供了一些有趣的线索。
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