Suppr超能文献

一氧化氮介导梗死后期重塑过程中血管紧张素 II 2 型受体过表达的益处。

Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling.

作者信息

Bove Christina M, Yang Zequan, Gilson Wesley D, Epstein Frederick H, French Brent A, Berr Stuart S, Bishop Sanford P, Matsubara Hiroaki, Carey Robert M, Kramer Christopher M

机构信息

University of Virginia Health System, Departments of Medicine and Radiology, Lee Street, Box 800170, Charlottesville, VA 22908, USA.

出版信息

Hypertension. 2004 Mar;43(3):680-5. doi: 10.1161/01.HYP.0000115924.94236.91. Epub 2004 Jan 19.

Abstract

We hypothesized that nitric oxide (NO) mediates the benefits of cardiac angiotensin II type 2 (AT(2)-R) overexpression during postmyocardial infarction (post-MI) remodeling. Eleven wild-type (WT) C57BL/6 mice and 28 transgenic (TG) mice with AT(2)-R overexpression were studied by cardiac magnetic resonance imaging (CMR) at baseline and days 1 and 28 post-MI induced by left anterior descending artery occlusion and reperfusion. Sixteen TG mice were treated from day 1 through 28 post-MI with the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester in drinking water at 1 mg/mL (TG-Rx). Left ventricular mass index (LVMI), end-diastolic volume index (EDVI) and end-systolic volume index (ESVI), wall thickness, percent thickening, and ejection fraction (EF) were measured. Infarct size on day 1 was assessed by post-contrast CMR. Interstitial collagen was quantified in noninfarcted regions. At baseline, heart rate (HR), blood pressure (BP), LVMI, EDVI, and ESVI were similar between groups, as were infarct size and weekly post-MI HR and systolic BP. By day 28 post-MI, EDVI and ESVI were similar in WT and TG-Rx, but significantly lower in TG (ESVI: 1.41+/-0.18 microL/g versus 2.53+/-0.14 microL/g in WT; 2.17+/-0.14 microL/g in TG-Rx; P<0.008 for both). At day 28, EF was higher in TG (46.3%+/-2.9%) compared with WT and TG-Rx (32.7+/-2.3% and 33.7+/-2.3, respectively; P<0.003 for both). Wall thickening at day 28 post-MI was greater in the base and mid-LV in TG than WT and TG-Rx. Noninfarcted region interstitial collagen was similar between groups. Thus, the NO pathway may mediate much of the benefits of cardiac AT(2)-R overexpression during post-MI remodeling.

摘要

我们假设一氧化氮(NO)介导心肌梗死后(post-MI)重塑过程中心脏血管紧张素II 2型受体(AT(2)-R)过表达的益处。通过心脏磁共振成像(CMR)对11只野生型(WT)C57BL/6小鼠和28只AT(2)-R过表达的转基因(TG)小鼠进行研究,研究在基线以及左前降支动脉闭塞和再灌注诱导的心肌梗死后第1天和第28天进行。16只TG小鼠在心肌梗死后第1天至第28天用饮用水中浓度为1 mg/mL的NO合酶抑制剂N(G)-硝基-L-精氨酸甲酯进行处理(TG-Rx)。测量左心室质量指数(LVMI)、舒张末期容积指数(EDVI)和收缩末期容积指数(ESVI)、壁厚、增厚百分比和射血分数(EF)。通过对比增强CMR评估第1天的梗死面积。对非梗死区域的间质胶原进行定量分析。在基线时,两组之间的心率(HR)、血压(BP)、LVMI、EDVI和ESVI相似,梗死面积以及心肌梗死后每周的HR和收缩压也相似。到心肌梗死后第28天,WT和TG-Rx组的EDVI和ESVI相似,但TG组显著更低(ESVI:TG组为1.41±0.18 μL/g,WT组为2.53±0.14 μL/g;TG-Rx组为2.17±0.14 μL/g;两组均P<0.008)。在第28天,TG组的EF高于WT组和TG-Rx组(分别为46.3%±2.9%、32.7±2.3%和33.7±2.3%;两组均P<0.003)。心肌梗死后第28天,TG组左心室底部和中部的壁增厚大于WT组和TG-Rx组。各组非梗死区域的间质胶原相似。因此,NO途径可能介导了心肌梗死后重塑过程中心脏AT(2)-R过表达的大部分益处。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验