Stastny P
N Engl J Med. 1978 Apr 20;298(16):869-71. doi: 10.1056/NEJM197804202981602.
Previous testing of patients with rheumatoid arthritis showed that one HLA-D type, Dw4, occurred more frequently than in normal controls. B-cell alloantigens closely related to HLA-D can now be identified by a simple serologic procedure. Using this test, I studied 80 white patients with erosive, rheumatoid-factor-positive rheumatoid arthritis. The B-cell alloantigen HLA-DRw4 occurred in 70 per cent of 54 patients, as compared to 28 per cent of the 68 normal controls (P less than 10(-5)). Both groups were also tested for the HLA-A, B and C antigens and for HLA-D. HLA-Dw4 occurred in 54 per cent of the patients and 16 per cent of the controls (P less than 10(-5)). Small differences observed in several of the HLA-A and B antigens were not statistically significant. The results indicate that rheumatoid arthritis in whites is associated with genes of the HLA-D region and that immunogenetic factors linked to HLA have a role in its pathogenesis.
先前对类风湿性关节炎患者的检测表明，一种HLA - D类型，即Dw4，在患者中出现的频率高于正常对照组。现在可以通过一种简单的血清学方法鉴定与HLA - D密切相关的B细胞同种抗原。利用这项检测，我研究了80例患有侵蚀性、类风湿因子阳性的类风湿性关节炎的白人患者。在54例患者中，B细胞同种抗原HLA - DRw4出现在70%的患者中，相比之下，68例正常对照组中只有28%出现该抗原（P小于10^(-5)）。两组患者还进行了HLA - A、B和C抗原以及HLA - D的检测。HLA - Dw4出现在54%的患者中，而对照组中为16%（P小于10^(-5)）。在一些HLA - A和B抗原中观察到的微小差异无统计学意义。结果表明，白人的类风湿性关节炎与HLA - D区域的基因相关，并且与HLA相关的免疫遗传因素在其发病机制中起作用。
