Rentz Dorene M, Huh Terri J, Faust Robert R, Budson Andrew E, Scinto Leonard F M, Sperling Reisa A, Daffner Kirk R
Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Neuropsychology. 2004 Jan;18(1):38-49. doi: 10.1037/0894-4105.18.1.38.
Identifying high-functioning older individuals in preclinical phases of Alzheimer's disease (AD) may require more sensitive methods than the standard approach. The authors explored the utility of adjusting for premorbid intelligence to predict progressive cognitive decline or Mild Cognitive Impairment (MCI) in 42 highly intelligent older individuals. When scores were adjusted for baseline IQ, 9 participants had executive impairments, 11 had memory impairments, and 22 scored in the normal range. None were impaired according to standard age norms. Three and a half years later, 9 participants with IQ-adjusted memory impairment declined in naming, visuospatial functioning, and memory; 6 convened to MCI. Three participants with normal memory declined. Implications for using IQ-adjusted norms to predict preclinical AD are discussed.
识别处于阿尔茨海默病（AD）临床前期的高功能老年人可能需要比标准方法更敏感的方法。作者探讨了在42名高智商老年人中，调整病前智力以预测渐进性认知衰退或轻度认知障碍（MCI）的效用。当根据基线智商调整分数时，9名参与者存在执行功能障碍，11名存在记忆障碍，22名得分在正常范围内。按照标准年龄规范，无人受损。三年半后，9名经智商调整存在记忆障碍的参与者在命名、视觉空间功能和记忆方面出现衰退；6人发展为MCI。3名记忆正常的参与者出现衰退。文中讨论了使用经智商调整的规范来预测临床前期AD的意义。
