与图谱坐标相比，磁共振成像和微电极记录所靶向的丘脑底核位置的变异性。
Variability in position of the subthalamic nucleus targeted by magnetic resonance imaging and microelectrode recordings as compared to atlas co-ordinates.
作者信息
Littlechild P, Varma T R K, Eldridge P R, Fox S, Forster A, Fletcher N, Steiger M, Byrne P, Tyler K, Flintham S
机构信息
The Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
出版信息
Stereotact Funct Neurosurg. 2003;80(1-4):82-7. doi: 10.1159/000075164.
BACKGROUND
Traditional methods for localisation of target nuclei for deep brain stimulation (DBS) have used brain atlas co-ordinates for initial targeting. It is now possible to visualise the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) and determine the individual variability of its position.
METHODS
The present study was performed in patients undergoing STN DBS for Parkinson's disease. The STN was directly targeted from axially obtained MRI and verified with microelectrode recordings. Postoperatively, the most effective contact was identified for each patient, and its position was calculated.
RESULTS
Fifty electrodes were inserted in 25 patients. The target position varied considerably in relation to the mid-commissural point. The mean effective contact position lies just dorsal to the location of the STN in a standard brain atlas.
CONCLUSION
The STN varies in position, and can be accurately targeted from MRI alone.
背景
用于深部脑刺激（DBS）的目标核团定位的传统方法一直采用脑图谱坐标进行初始定位。现在可以在磁共振成像（MRI）上可视化丘脑底核（STN），并确定其位置的个体变异性。
方法
本研究在接受用于帕金森病的STN-DBS的患者中进行。STN直接从轴向获取的MRI上进行定位，并用微电极记录进行验证。术后，为每位患者确定最有效的触点，并计算其位置。
结果
25例患者共插入50根电极。目标位置相对于连合中点有很大差异。平均有效触点位置恰好在标准脑图谱中STN位置的背侧。
结论
STN的位置存在变异，仅通过MRI就能准确地进行定位。
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