Choksi Neepa Y, Jahnke Gloria D, St Hilaire Cathy, Shelby Michael
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Birth Defects Res B Dev Reprod Toxicol. 2003 Dec;68(6):479-91. doi: 10.1002/bdrb.10045.
The highly conserved nature of the thyroid gland and the thyroid system among mammalian species suggests it is critical to species survival. Studies show the thyroid system plays a critical role in the development of several organ systems, including the reproductive tract. Despite its highly conserved nature, the thyroid system can have widely different effects on reproduction and reproductive tract development in different species. The present review focuses on assessing the role of thyroid hormones in human reproduction and reproductive tract development and comparing it to the role of thyroid hormones in laboratory animal reproduction and reproductive tract development. The review also assesses the effects of thyroid dysfunction on reproductive tract development and function in humans and laboratory animals. Consideration of such information is important in designing, conducting, and interpreting studies to assess the potential effects of thyroid toxicants on reproduction and development.
甲状腺和甲状腺系统在哺乳动物物种中具有高度保守的特性，这表明它对物种生存至关重要。研究表明，甲状腺系统在包括生殖道在内的多个器官系统的发育中起着关键作用。尽管其具有高度保守的特性，但甲状腺系统在不同物种中对生殖和生殖道发育可能有广泛不同的影响。本综述着重评估甲状腺激素在人类生殖和生殖道发育中的作用，并将其与甲状腺激素在实验动物生殖和生殖道发育中的作用进行比较。该综述还评估了甲状腺功能障碍对人类和实验动物生殖道发育及功能的影响。在设计、开展和解释评估甲状腺毒物对生殖和发育潜在影响的研究时，考虑此类信息很重要。
