大鼠门腔分流术后右肾动脉对门静脉残端的动脉化作用

Arterialization of the portal stump by right renal artery after portocaval shunt in the rat.

作者信息

Li Destri Giovanni, La Greca Gaetano, Greco Luigi, Greco Raffaele, Licitra Edelweiss, Lanteri Raffaele, Di Cataldo Antonio

机构信息

Department of Surgical Sciences, Organ Transplantations, and Advanced Technologies, University of Catania, Catania, Italy.

出版信息

Microsurgery. 2004;24(1):77-80. doi: 10.1002/micr.10197.

DOI:10.1002/micr.10197

PMID:14748031

Abstract

Portosystemic shunts cause severe secondary effects, so that arterializations of the portal stump are planned to increase the blood supply to the liver. The aim of this study was to verify the technical feasibility of arterialization of the portal stump with the right renal artery in order to obtain a valid experimental model to study the pathophysiology of arterial revascularization of the liver. Twenty rats underwent end-to-side portocaval shunt + end-to-end anastomosis between the right renal artery and portal stump; another 20 rats were subjected to the same surgical procedure, but the portal stump underwent a reduction in size. In our study, both techniques gave good results, but the use of an operating microscope and good microsurgical training were essential in achieving a good patency rate (78.3%).

摘要

门体分流会导致严重的继发效应，因此计划进行门静脉残端动脉化以增加肝脏的血液供应。本研究的目的是验证用右肾动脉进行门静脉残端动脉化的技术可行性，以便获得一个有效的实验模型来研究肝脏动脉血运重建的病理生理学。20只大鼠接受了端侧门腔分流术 + 右肾动脉与门静脉残端之间的端端吻合术；另外20只大鼠接受相同的手术操作，但门静脉残端进行了缩窄。在我们的研究中，两种技术都取得了良好的效果，但使用手术显微镜和良好的显微外科训练对于实现良好的通畅率（78.3%）至关重要。