Levy Angela D, Abbott Robert M, Abbondanzo Susan L
Departments of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306-6000, USA.
Radiology. 2004 Feb;230(2):485-90. doi: 10.1148/radiol.2302030196.
To evaluate the clinical, pathologic, and computed tomographic (CT) features of littoral cell angioma of the spleen in eight patients.
Two abdominal radiologists retrospectively reviewed the contrast material-enhanced CT images obtained in six, the contrast-enhanced and nonenhanced CT images obtained in two, and the photographs of gross pathologic specimens resected from seven patients. They also retrospectively reviewed clinical data (ie, demographic data, presenting signs and symptoms, physical findings, and medical histories). Histopathologic specimens from the eight patients were reviewed by a hematopathologist. The CT images were reviewed for the presence of splenomegaly. The number, size, and enhancement characteristics of the splenic masses at CT were compared with the histopathologic and gross pathologic specimen findings.
All patients had laboratory evidence of hypersplenism. Seven patients (88%) had splenomegaly and innumerable splenic masses ranging from 0.2 to 6.0 cm in diameter at CT. The single patient with a normal spleen size had four splenic masses. The splenic masses were hypoattenuating relative to the normal spleen at CT in all patients and correlated with blood-filled nodules at gross pathologic examination and with blood-filled vascular channels of littoral cell angioma at histopathologic examination. The early and late portal venous phase CT images that were available in one case demonstrated progressive homogeneous contrast enhancement of the masses such that they were indistinguishable from the normal splenic parenchyma.
Littoral cell angioma is a primary splenic neoplasm that most commonly manifests at CT as multiple hypoattenuating masses in an enlarged spleen. Histopathologically, these masses represent blood-filled vascular channels.
评估8例脾脏沿岸细胞血管瘤的临床、病理及计算机断层扫描（CT）特征。
两名腹部放射科医生回顾性分析了6例患者的对比剂增强CT图像、2例患者的增强和非增强CT图像以及7例患者切除的大体病理标本照片。他们还回顾性分析了临床资料（即人口统计学数据、临床表现和症状、体格检查结果及病史）。8例患者的组织病理学标本由血液病理学家进行检查。对CT图像进行脾肿大情况评估。将CT上脾脏肿块的数量、大小及增强特征与组织病理学和大体病理标本结果进行比较。
所有患者均有脾功能亢进的实验室证据。7例患者（88%）脾肿大，CT显示脾脏有无数直径为0.2至6.0 cm的肿块。脾脏大小正常的1例患者有4个脾脏肿块。所有患者CT上脾脏肿块相对于正常脾脏呈低密度，大体病理检查显示与充血结节相关，组织病理学检查显示与沿岸细胞血管瘤的充血血管通道相关。1例患者可获得的门静脉早期和晚期CT图像显示肿块呈渐进性均匀强化，以至于与正常脾实质难以区分。
沿岸细胞血管瘤是一种原发性脾脏肿瘤，在CT上最常见的表现为脾肿大内多个低密度肿块。组织病理学上，这些肿块代表充血的血管通道。
