细胞周期进程与癌症中的多梳蛋白家族蛋白
Polycomb group proteins in cell cycle progression and cancer.
作者信息
Pasini Diego, Bracken Adrian P, Helin Kristian
机构信息
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
出版信息
Cell Cycle. 2004 Apr;3(4):396-400. Epub 2004 Apr 1.
PMID:14752272
Abstract
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
摘要
基因表达的表观遗传失调正逐渐成为肿瘤发生的关键机制。染色质重塑多梳抑制复合物2（PRC2）的活性失调最近被证明是人类肿瘤中的常见事件。在此，我们讨论这些发现，并推测PRC2复合物在正常细胞增殖和癌症发展过程中控制基因表达的作用。
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