Saarel Elizabeth Vickers, Stefanelli Christopher B, Fischbach Peter S, Serwer Gerald A, Rosenthal Amnon, Dick Macdonald
Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan 48109-0204, USA.
Pediatrics. 2004 Feb;113(2):248-51. doi: 10.1542/peds.113.2.248.
Patient-activated transtelephonic electrocardiographic event monitors (TTMs) are often used for the evaluation of children and adolescents with suspected arrhythmias. Since their introduction 25 years ago, there has been little inquiry quantifying the usefulness of TTMs for pediatric patients. The objective of this study was to measure the utility of TTMs for children and adolescents with symptoms of a possible cardiac rhythm disturbance.
Medical records of all patients who received TTMs from C.S. Mott Children's Hospital Electrocardiography Laboratory between February 1, 1993, and October 31, 2000, were reviewed. Patients with pacemakers, known arrhythmias, or age older than 18 years were excluded. Indications for monitoring included palpitations with or without other symptoms (N = 420), chest discomfort (N = 43), and presyncope or syncope (N = 32).
A total of 495 studies (patient mean age: 10.2 +/- 4.3 years; range: 0.1-17.9 years; 48% male) met inclusion criteria. Monitoring was performed for 1 to 1021 consecutive days (mean: 103 +/- 97). Fifty-two percent (N = 257) of patients failed to transmit an electrocardiogram while experiencing symptoms. Fewer boys transmitted electrocardiograms (N = 100/238). Of 238 symptomatic patients, 15% (N = 35; mean age: 11.4 +/- 4.7 years; range: 0.1-17.4 years; 51% male) had supraventricular tachycardia (SVT). No other significant arrhythmia that may warrant treatment was identified. All patients with SVT had palpitations. No patients with isolated chest discomfort, presyncope, or syncope had SVT (N = 75). SVT was documented more frequently in patients with postevent (N = 35/464) than loop recorders (N = 0/31). Of those with SVT, 71% (N = 25) and 91% (N = 33) transmitted events within 4 and 16 weeks, respectively. Follow-up for 1 to 108 months (mean: 32 +/- 25; median: 26) in 53% (243 of 460) of patients without SVT uncovered a 3% (N = 7) rate of subsequent SVT detection. The overall sensitivity of the TTM test was 83% (35 of 42) for detection of SVT. The sensitivity of studies theoretically limited to 4 and 16 weeks would be 60% (25 of 42) and 79% (33 of 42), respectively. The negative predictive value of the TTM study was 99% in our patient population. The negative predictive value of tests theoretically limited to 4 and 16 weeks would be 96% and 98%, respectively. TTM studies of 2 weeks' duration were most cost-effective in terms of total diagnostic yield. In contrast, studies of 4 weeks' duration were most cost-efficient for SVT detection.
TTMs are useful for the evaluation of children and adolescents with palpitations but not with isolated chest pain, syncope, or presyncope. In this study, girls were more likely to transmit events. The sensitivity of TTMs for detection of SVT was 83%. The negative predictive value of the TTM test was 99%. Monitoring for longer than 16 weeks did not increase test sensitivity. Studies of 4 weeks' duration proved most cost-effective for SVT detection.
患者激活的经电话心电图事件监测仪(TTM)常用于评估疑似心律失常的儿童和青少年。自25年前引入以来,很少有研究对TTM在儿科患者中的实用性进行量化评估。本研究的目的是衡量TTM对有心脏节律紊乱症状的儿童和青少年的效用。
回顾了1993年2月1日至2000年10月31日期间在C.S. 莫特儿童医院心电图实验室接受TTM检查的所有患者的病历。排除有起搏器、已知心律失常或年龄超过18岁的患者。监测指征包括伴有或不伴有其他症状的心悸(N = 420)、胸部不适(N = 43)以及先兆晕厥或晕厥(N = 32)。
共有495项研究(患者平均年龄:10.2±4.3岁;范围:0.1 - 17.9岁;48%为男性)符合纳入标准。监测持续1至1021天(平均:103±97天)。52%(N = 257)的患者在出现症状时未能传输心电图。传输心电图的男孩较少(N = 100/238)。在238名有症状的患者中,15%(N = 35;平均年龄:11.4±4.7岁;范围:0.1 - 17.4岁;51%为男性)患有室上性心动过速(SVT)。未发现其他可能需要治疗的明显心律失常。所有患有SVT的患者都有心悸。没有孤立性胸部不适、先兆晕厥或晕厥的患者患有SVT(N = 75)。事件后监测(N = 35/464)比环路记录仪(N = 0/31)更频繁地记录到SVT。在患有SVT的患者中,分别有71%(N = 25)和91%(N = 33)在4周和第16周内传输了事件。在53%(460名中的243名)无SVT的患者中进行了1至108个月(平均:32±25;中位数:2)的随访,发现后续SVT检出率为3%(N = 7)。TTM检测SVT的总体敏感性为83%(42名中的35名)。理论上限制在4周和16周的研究敏感性分别为60%(42名中的25名)和79%(42名中的33名)。在我们的患者群体中,TTM研究的阴性预测值为99%。理论上限制在4周和16周的检测阴性预测值分别为96%和98%。就总诊断率而言,持续2周的TTM研究最具成本效益。相比之下,持续4周的研究对SVT检测最具成本效益。
TTM对评估有心悸症状的儿童和青少年有用,但对孤立性胸痛、晕厥或先兆晕厥无用。在本研究中,女孩更有可能传输事件。TTM检测SVT的敏感性为83%。TTM检测的阴性预测值为99%。监测超过16周并未提高检测敏感性。持续4周的研究被证明对SVT检测最具成本效益。