Lin Changxue, Fu Hua, Zhao Yufen
Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China.
Rapid Commun Mass Spectrom. 2004;18(3):273-7. doi: 10.1002/rcm.1324.
New anti-HIV prodrugs, conjugates of AZT and d4T with boranophosphates, were prepared by the H-phosphonate method. Their structures were determined by negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated, and most of the fragment ions contained the boranophosphate or phosphinate group.
通过H-膦酸酯法制备了新的抗HIV前药，即叠氮胸苷（AZT）和双脱氧胸苷（d4T）与硼烷磷酸盐的缀合物。通过负离子电喷雾电离质谱（ESI-MS）结合串联质谱（MS/MS）确定了它们的结构。研究了裂解途径，大多数碎片离子含有硼烷磷酸盐或次膦酸酯基团。
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