[原发性乳腺癌至腋窝淋巴结转移过程中激素受体表达的丧失]

[Loss of hormonal receptors expression from primary breast carcinoma to axillary lymph node metastases].

作者信息

Cianga Corina, Cianga P, Cozma Laurette, Diaconu C, Carasevici E

机构信息

Disciplina Imunologie, Facultatea de Medicină Stomatologică, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2003 Jul-Sep;107(3):540-4.

PMID:14756058

Abstract

Breast tumors growth is regulated by female sex steroid hormones. The level of the estrogen and progesterone receptors (ER and PR) expression by the malignant cells is important for the evaluation of the tumor prognostic and the benefit of a hormonal therapy. The aim of our study was to identify the expression of estrogen and progesterone receptors in primary breast tumors and in the corresponding axillary lymph nodes metastases, in 24 cases. The results showed that more than 30% of poorly differentiated breast carcinomas lost their expression of hormone receptors from the primary tumors to axillary metastases, an event which can be associated with an aggressive tumoral behaviour and resistance to hormonal therapy.

摘要

乳腺肿瘤的生长受女性甾体激素调节。恶性细胞中雌激素和孕激素受体（ER和PR）的表达水平对于评估肿瘤预后及激素治疗的获益情况很重要。我们研究的目的是确定24例原发性乳腺肿瘤及其相应腋窝淋巴结转移灶中雌激素和孕激素受体的表达情况。结果显示，超过30%的低分化乳腺癌从原发性肿瘤到腋窝转移灶失去了激素受体表达，这一情况可能与肿瘤的侵袭性行为及对激素治疗的抵抗有关。