条件性动物模型：一种确定癌基因何时会成为治疗癌症有效靶点的策略。

Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.

作者信息

Giuriato Sylvie, Rabin Karen, Fan Alice C, Shachaf Catherine M, Felsher Dean W

机构信息

Division of Oncology, Stanford University, CCSR 1105, 269 Campus Drive, Stanford, CA 94305-5151, USA.

出版信息

Semin Cancer Biol. 2004 Feb;14(1):3-11. doi: 10.1016/j.semcancer.2003.11.002.

DOI:10.1016/j.semcancer.2003.11.002

PMID:14757531

Abstract

The ability to model cancer in the mouse has provided a robust methodology to dissect the molecular etiology of cancer. These models serve as potentially powerful platforms to preclinically evaluate novel therapeutics. In particular, the recent development of strategies to conditionally induce the or knockout the function of genes in a tissue specific manner has enabled investigators to engineer mice to demonstrate that the targeted inactivation of specific oncogenes can be effective in inducing sustained regression of tumors. Thus, these animal models will be useful to define the specific genes that will be therapeutically useful to target for the treatment of particular human cancers.

摘要

在小鼠中构建癌症模型的能力为剖析癌症的分子病因提供了一种强大的方法。这些模型可作为临床前评估新型疗法的潜在有力平台。特别是，最近以组织特异性方式有条件地诱导基因功能或敲除基因功能的策略的发展，使研究人员能够构建小鼠模型，以证明特定癌基因的靶向失活可有效诱导肿瘤持续消退。因此，这些动物模型将有助于确定对治疗特定人类癌症具有治疗作用的特定基因。