Mazza Marcelo, de Pinho Marilene, Piqueira José Roberto C, Roque Antônio C
Departamento de Física e Matemática, FFCLRP, Universidade de São Paulo, São Paulo, Brazil.
J Comput Neurosci. 2004 Mar-Apr;16(2):177-201. doi: 10.1023/B:JCNS.0000014109.83574.78.
In this work we study the connection between some dynamic effects at the synaptic level and fast reorganization of cortical sensory maps. By using a biologically plausible computational model of the primary somatosensory system we obtained simulation results that can be used to relate the dynamics of the interactions of excitatory and inhibitory neurons to the process of somatotopic map reorganization immediately after peripheral lesion. The model consists of three regions integrated into a single structure: tactile receptors representing the glabrous surface of the hand, ventral posterior lateral nucleus of the thalamus and area 3b of the primary somatosensory cortex, reproducing the main aspects of the connectivity of these regions. By applying informational measures to the simulation results of the dynamic behavior of AMPA, NMDA and GABA synaptic conductances we draw some conjectures about how the several neuronal synaptic elements are related to the initial stage of the digit-induced reorganization of the hand map in the somatosensory cortex.
在这项工作中，我们研究了突触水平的一些动态效应与皮质感觉图谱快速重组之间的联系。通过使用一个具有生物学合理性的初级体感系统计算模型，我们获得了模拟结果，这些结果可用于将兴奋性和抑制性神经元相互作用的动力学与外周损伤后立即发生的躯体感觉图谱重组过程联系起来。该模型由整合在一个单一结构中的三个区域组成：代表手部无毛表面的触觉感受器、丘脑腹后外侧核和初级体感皮层的3b区，再现了这些区域连接性的主要方面。通过将信息测度应用于AMPA、NMDA和GABA突触电导动态行为的模拟结果，我们对体感皮层中几个神经元突触元件如何与手指诱导的手部图谱重组的初始阶段相关联提出了一些推测。
