Dudkin K N, Chueva I V, Makarov F N
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Ross Fiziol Zh Im I M Sechenova. 2003 Oct;89(10):1226-39.
Monkeys were taught to differentiate stimuli with different types of information and to perform a spatial choice. Development of Alzheimer's disease in experimental monkeys entailed a deficit of operative memory, a considerable enhancement of entropy related to correct decisions. In control monkeys, no significant changes of these characteristics occurred. In monkeys, following a bilateral removal of the sulcus principalis, the 7th field, or both, the operative memory deficit was also determined by two components. The specifics of disorders in the operative memory due to Alzheimer's disease suggest that cholinergic mechanisms determining the sensory processing differ from those involved in decision-making. The structural-functional organization of interaction between sensory and cognitive processes controlled by the motivation and attention system, is discussed.
猴子被训练区分带有不同类型信息的刺激并做出空间选择。实验猴子患阿尔茨海默病会导致操作记忆缺陷,与正确决策相关的熵显著增加。在对照猴子中,这些特征没有显著变化。在猴子身上,双侧切除主沟、第7区或两者后,操作记忆缺陷也由两个成分决定。阿尔茨海默病导致的操作记忆障碍的具体情况表明,决定感觉处理的胆碱能机制与参与决策的机制不同。本文讨论了由动机和注意力系统控制的感觉与认知过程之间相互作用的结构功能组织。