基于比较三维模型的大豆根瘤蛋白26的功能特性
Functional properties of soybean nodulin 26 from a comparative three-dimensional model.
作者信息
Biswas Sampa
机构信息
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
出版信息
FEBS Lett. 2004 Jan 30;558(1-3):39-44. doi: 10.1016/S0014-5793(03)01529-1.
Abstract
A model of the nodulin 26 channel protein has been constructed based on comparative modeling and molecular dynamics simulations. Structural features of the protein indicate a selectivity filter that differs from those of the known structures of Escherichia coli glycerol facilitator and mammalian aquaporin 1. The model structure also reveals important roles of Ser207 and Phe96 in ligand binding and transport.
摘要
基于比较建模和分子动力学模拟构建了结节素26通道蛋白的模型。该蛋白的结构特征表明其选择性过滤器与大肠杆菌甘油转运蛋白和哺乳动物水通道蛋白1的已知结构不同。模型结构还揭示了Ser207和Phe96在配体结合和转运中的重要作用。
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