Sucharzewska-Tomczak Malgorzata, Grzegorzewska Alicja E, Leander Magdalena
Nephrology Ward and Dialysis Unit, Medical Care Center, Ministry of Internal Affairs and Administration, Poznan, Poland.
Adv Perit Dial. 2003;19:246-50.
The aim of the present study was to establish a relationship between serum haptoglobin (HTG) concentration, peritoneal dialysis (PD) adequacy, and nutrition status in PD patients with and without diabetes. We measured serum concentrations of HTG, albumin, iron, and cholesterol; platelet count; transferrin saturation (TSAT); weekly Kt/V; and total weekly creatinine clearance (CCr) in 60 patients with and without diabetes who were being treated with continuous ambulatory PD or automated PD. The mean serum HTG concentration in PD patients without diabetes (2.5 +/- 1.2 g/L) was elevated and differed significantly from that in PD patients with diabetes (2.0 +/- 1.1 g/L). In patients without diabetes the correlation of serum HTG concentration with serum albumin level was r = -0.330 (p < 0.030), with platelet count was r = 0.320 (p < 0.040), with serum iron concentration was r = -0.450 (p < 0.002), with TSAT was r = -0.4200 (p < 0.005), and with age was r = 0.337 (p = 0.003). No such relationships were seen in patients with diabetes. In both subgroups, no dependence was seen between serum HTG concentration and weekly Kt/V, total weekly CCr, or serum cholesterol concentration. Serum HTG concentration in PD patients without diabetes may be a valid inflammatory marker. The HTG serum level displays a significant statistical dependence on age, platelet count, and markers of nutrition such as serum albumin level, iron, and TSAT. It does not depend on markers of dialysis adequacy (weekly Kt/V, total weekly CCr) or on serum cholesterol concentration. The serum HTG concentration in PD patients with diabetes is lower than that in patients without diabetes, and it is not related to examined factors of inflammation, nutrition, or adequacy of dialysis.
本研究的目的是在有糖尿病和无糖尿病的腹膜透析（PD）患者中，建立血清触珠蛋白（HTG）浓度、腹膜透析充分性和营养状况之间的关系。我们测量了60例接受持续性非卧床腹膜透析或自动化腹膜透析治疗的有糖尿病和无糖尿病患者的血清HTG、白蛋白、铁、胆固醇浓度、血小板计数、转铁蛋白饱和度（TSAT）、每周Kt/V以及每周总肌酐清除率（CCr）。无糖尿病的PD患者血清HTG平均浓度（2.5±1.2 g/L）升高，与有糖尿病的PD患者（2.0±1.1 g/L）有显著差异。在无糖尿病患者中，血清HTG浓度与血清白蛋白水平的相关性为r = -0.330（p < 0.030），与血小板计数为r = 0.320（p < 0.040），与血清铁浓度为r = -０.450（p < 0.002），与TSAT为r = -0.4200（p < 0.005），与年龄为r = 0.337（p = 0.003）。在有糖尿病患者中未观察到此类关系。在两个亚组中，均未观察到血清HTG浓度与每周Kt/V、每周总CCr或血清胆固醇浓度之间存在相关性。无糖尿病的PD患者血清HTG浓度可能是一个有效的炎症标志物。HTG血清水平与年龄、血小板计数以及营养标志物如血清白蛋白水平、铁和TSAT存在显著的统计学相关性。它不依赖于透析充分性标志物（每周Kt/V、每周总CCr）或血清胆固醇浓度。有糖尿病的PD患者血清HTG浓度低于无糖尿病患者，且与所检测的炎症、营养或透析充分性因素无关。
