奥昔米定III，一种针对假单胞菌属II型转化细胞的新型抗肿瘤抗生素。II. 结构解析。

Oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. II. Structure elucidation.

作者信息

Hayakawa Yoichi, Tomikawa Taijiro, Shin-ya Kazuo, Arao Nakako, Nagai Koji, Suzuki Ken-ichi, Furihata Kazuo

机构信息

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.

出版信息

J Antibiot (Tokyo). 2003 Nov;56(11):905-8. doi: 10.7164/antibiotics.56.905.

DOI:10.7164/antibiotics.56.905

PMID:14763555

Abstract

The structure of oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. QN05727, was determined to be a benzolactone enamide containing an O-methyloxime moiety as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques.

摘要

氧代米丁III是一种对来自假单胞菌属QN05727的转化细胞具有抗肿瘤活性的新型抗生素，通过包括多种二维技术在内的核磁共振光谱分析确定其结构为含有O - 甲基肟部分的苯并内酯烯酰胺，如图1所示。