颞叶癫痫患者脑组织中的疱疹病毒DNA。
Herpesviral DNA in brain tissue from patients with temporal lobe epilepsy.
作者信息
Eeg-Olofsson O, Bergström T, Andermann F, Andermann E, Olivier A, Rydenhag B
机构信息
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. orvar@
出版信息
Acta Neurol Scand. 2004 Mar;109(3):169-74. doi: 10.1046/j.1600-0404.2003.00238.x.
OBJECTIVES
Presence of DNA from six herpesviruses were examined in brain tissue from patients operated for temporal lobe epilepsy.
MATERIAL AND METHODS
A total of 19 Canadian patients (I) with a median age of 22 years, 17 Swedish patients (II) with a median age of 14 years and a reference group comprising 12 individuals were studied. Presence of herpesviral DNA was detected by nested polymerase chain reaction.
RESULTS
Of three children with Rasmussen's encephalitis, Cytomegalovirus (CMV) DNA was found in two, and human herpesvirus type 6 DNA in two. In six children with ganglioglioma, Epstein-Barr virus (EBV) was detected in four. CMV DNA was found significantly more in group I compared with II, while the reverse occurred with EBV DNA. Malformations of cortical development were found significantly more in group II compared with I.
CONCLUSION
Detection of DNA from some herpesviruses in epileptic brain tissue may possibly be associated with distinct clinical conditions, but factors such as age and malformations of cortical development should also be considered.
目的
检测接受颞叶癫痫手术患者脑组织中六种疱疹病毒的DNA。
材料与方法
共研究了19名加拿大患者（I组），中位年龄22岁；17名瑞典患者（II组），中位年龄14岁；以及一个由12名个体组成的对照组。通过巢式聚合酶链反应检测疱疹病毒DNA的存在情况。
结果
在三名患有拉斯穆森脑炎的儿童中，两名检测到巨细胞病毒（CMV）DNA，两名检测到人类疱疹病毒6型DNA。在六名患有神经节胶质瘤的儿童中，四名检测到爱泼斯坦-巴尔病毒（EBV）。与II组相比，I组中CMV DNA的检出率显著更高，而EBV DNA的情况则相反。与I组相比，II组中皮质发育畸形的发生率显著更高。
结论
在癫痫脑组织中检测到某些疱疹病毒的DNA可能与特定临床情况有关，但年龄和皮质发育畸形等因素也应予以考虑。
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