多倍体与癌症；正常、癌前及肿瘤大鼠组织细胞核的脱氧戊糖核酸含量
Polyploidy and cancer; the desoxypentosenucleic acid content of nuclei of normal, precancerous, and neoplastic rat tissues.
作者信息
CUNNINGHAM L, GRIFFIN A C, LUCK J M
出版信息
J Gen Physiol. 1950 Sep;34(1):59-63. doi: 10.1085/jgp.34.1.59.
Abstract
The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10(-6) micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues.
摘要
测定了大鼠各种正常组织、肿瘤组织以及呈现癌前变化的肝脏中单个细胞核的平均脱氧戊糖核酸含量。除了某些因多倍体导致的例外情况，这些数值彼此之间以及与其他哺乳动物细胞核所报告的数值实际上没有区别。大鼠二倍体细胞中这种核酸的含量似乎是一个常数，几乎等于6×10⁻⁶微克。因此，在呈现肿瘤前或肿瘤性变化的组织中这种核酸浓度增加的发现证实了此类组织中细胞增多和多倍体增加的组织学观察结果。
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