Takeshita A, Tanaka S, Orita Y, Kanaide H, Nakamura M
Circulation. 1977 May;55(5):803-6. doi: 10.1161/01.cir.55.5.803.
Takayasu's aortitis is an arterial inflammatory disease of arteries of unknown etiology. Fainting is a common symptom and has been attributed to ypersensitivity of the baroreflex. We studied baroreflex sensitivity in 11 patients with Takayasu's aortitis and compared it with that of eight control subjects of comparable age. Baroreflex sensitivity was assessed by determining the slope of a regression line relating the rise of systolic arterial pressure to the prolongation of the R-R interval of the electrocardiogram during a transient rise of arterial pressure induced by an intravenous injection of phenylephrine. The average baroreflex slope of patients with Takayasu's arteritis (4.0 +/- 0.8 msec/mm Hg) was significantly less than that of control subjects (10.7 +/- 0.8 msec/mm Hg, P less than 0.001). Reduced baroreflex sensitivity in patients with Takayasu's aortitis may be due to the hardening of the arteries where baroreceptors lie, or to hypertension and/or cardiac disease which was present in most of the patients included in this study. Patients with Takayasu's aortitis who complained of fainting also showed the reduced baroreflex sensitivity. This indicates that fainting in this disease is not likely to be caused by the hyperreactivity of the baroreceptors as is commonly postulated.
高安动脉炎是一种病因不明的动脉炎性疾病。昏厥是常见症状，一直被归因于压力感受器反射过敏。我们研究了11例高安动脉炎患者的压力感受器反射敏感性，并将其与8名年龄相仿的对照受试者进行比较。通过在静脉注射去氧肾上腺素诱导动脉压短暂升高期间，确定收缩期动脉压升高与心电图R-R间期延长之间回归直线的斜率，来评估压力感受器反射敏感性。高安动脉炎患者的平均压力感受器反射斜率（4.0±0.8毫秒/毫米汞柱）显著低于对照受试者（10.7±0.8毫秒/毫米汞柱，P<0.001）。高安动脉炎患者压力感受器反射敏感性降低可能是由于压力感受器所在动脉的硬化，或者是由于本研究中大多数患者存在的高血压和/或心脏病。主诉昏厥的高安动脉炎患者也表现出压力感受器反射敏感性降低。这表明该疾病中的昏厥不太可能如通常所推测的那样是由压力感受器的反应过度引起的。
