胃癌与癌前胃病变的解剖分布比较。
Comparison of the anatomic distribution of stomach cancer and precancerous gastric lesions.
作者信息
You W C, Blot W J, Chang Y S, Li J Y, Jin M, Zhao Y X, Kneller R W, Xie Y Q, Zhang L, Xu G W
机构信息
Beijing Institute for Cancer Research, China.
出版信息
Jpn J Cancer Res. 1992 Nov;83(11):1150-3. doi: 10.1111/j.1349-7006.1992.tb02738.x.
The anatomic distribution of precancerous gastric lesions among 3,400 residents in Linqu, Shandong Province of China, was compared with the anatomic distribution of stomach cancer (SC) among 959 patients in Tokyo, Japan. The incidence of SC is high in both areas, and locations within the stomach of the precancerous and malignant lesions were classified using similar criteria. Chronic atrophic gastritis (CAG) affected 98% of the population in Linqu, with intestinal metaplasia (IM) the most severe diagnosis in 33% and dysplasia (DYS) in 20%. Neither the SC nor precancerous lesions were uniformly distributed in the stomach. Among the DYS 3% were along the greater curvature of the body, 15% along the lesser curvature of the body, 25% in the angulus, 22% along the lesser curvature of the antrum, and 34% elsewhere in the antrum. Among the SC the corresponding percentages were 2, 16, 28, 25 and 29. The similarity to the SC distribution increased gradually from CAG to IM to DYS, providing further evidence for the multistage progression of precancerous gastric lesions.
对中国山东省临朐县3400名居民的癌前胃病变的解剖分布情况，与日本东京959例胃癌（SC）患者的解剖分布情况进行了比较。这两个地区的胃癌发病率都很高，癌前病变和恶性病变在胃内的位置采用相似的标准进行分类。慢性萎缩性胃炎（CAG）在临朐县98%的人群中存在，33%的人诊断为最严重的肠化生（IM），20%的人诊断为发育异常（DYS）。胃癌和癌前病变在胃内均非均匀分布。在发育异常中，3%位于胃体大弯侧，15%位于胃体小弯侧，25%位于角切迹，22%位于胃窦小弯侧，34%位于胃窦其他部位。在胃癌中，相应的百分比分别为2%、16%、28%、25%和29%。从慢性萎缩性胃炎到肠化生再到发育异常，与胃癌分布的相似性逐渐增加，为癌前胃病变的多阶段进展提供了进一步证据。
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