Kinsley C H, Mann P E, Bridges R S
Department of Psychology, University of Richmond, VA 23173.
Physiol Behav. 1992 Nov;52(5):925-8. doi: 10.1016/0031-9384(92)90372-9.
Prenatally stressed (P-S) males show reductions in male sexual behavior, medial preoptic area volume, and levels of circulating testosterone. We examined the luteinizing hormone (LH) response to the presence of a sexually receptive female, a known index of sexual arousal. Adult male offspring from mothers stressed on days 15-22 of pregnancy (thrice-daily exposures to heat, light, and restraint) were implanted with an intraatrial catheter. Forty-eight h later they were placed into test chambers divided by a wire mesh partition; the catheter was extended outside the chamber. Thirty min later a baseline blood sample (time 0 min) was taken and a sexually receptive female was then placed on the side of the partition opposite the male for 60 min. Blood samples were collected 5, 10, 15, 30, 60 min, and 24 h after introduction of the female. Prenatally stressed males exhibited significantly lower LH levels following exposure to the female at each time point, 5 min to 24 h. Furthermore, at no point were P-S males' LH levels significantly increased above baseline levels. These data suggest that attenuations in female-induced LH release are associated with the marked reductions in male sexual behavior characteristic of the P-S male.
产前应激（P-S）雄性大鼠的性行为、内侧视前区体积和循环睾酮水平均有所降低。我们检测了促黄体生成素（LH）对性接受期雌性大鼠出现的反应，这是一种已知的性唤起指标。将孕期第15至22天受到应激（每天三次暴露于高温、光照和束缚）的成年雄性后代植入心房内导管。48小时后，将它们放入由金属丝网隔板隔开的测试室中；导管延伸到室外部。30分钟后采集基线血样（时间0分钟），然后将一只性接受期雌性大鼠放在隔板另一侧与雄性大鼠相对的位置60分钟。在引入雌性大鼠后的5、10、15、30、60分钟和24小时采集血样。在雌性大鼠暴露后的每个时间点（5分钟至24小时），产前应激雄性大鼠的LH水平均显著较低。此外，P-S雄性大鼠的LH水平在任何时候都没有显著高于基线水平。这些数据表明，雌性诱导的LH释放减弱与P-S雄性大鼠典型的性行为显著减少有关。
