TAGER M, LODGE A L
J Exp Med. 1951 Jul 1;94(1):73-85. doi: 10.1084/jem.94.1.73.
The conversion of plasma to serum results in a variable loss of the coagulase-reacting factor (C.R.F.) of the plasma. The C.R.F. loss is incurred during the process of prothrombin conversion: conditions which favor the most effective prothrombin conversion result in maximal C.R.F. loss, while factors which interfere with prothrombin conversion spare the C.R.F. In a system containing an adequate concentration of calcium, thrombo-plastin, and prothrombin, the C.R.F. loss reflects the amount of prothrombin conversion-accelerating substances (factor V or AC globulin). If fibrin clots are produced directly by thrombin, and prothrombin conversion is excluded, there is no significant C.R.F. loss.
血浆转化为血清会导致血浆中凝固酶反应因子(C.R.F.)不同程度的损失。C.R.F.的损失发生在凝血酶原转化过程中:有利于最有效凝血酶原转化的条件会导致最大程度的C.R.F.损失,而干扰凝血酶原转化的因素则可使C.R.F.得以保留。在含有足够浓度钙、凝血活酶和凝血酶原的系统中,C.R.F.的损失反映了凝血酶原转化加速物质(因子V或AC球蛋白)的量。如果由凝血酶直接产生纤维蛋白凝块,且排除凝血酶原转化过程,则不会有明显的C.R.F.损失。