Uchida Y, Yoshimoto N, Murao S
Jpn Heart J. 1978 Jan;19(1):112-24. doi: 10.1536/ihj.19.112.
The effect of a new chemical agent, SG 75, on coronary blood flow of anesthetized dogs has been examined. Intravenous administrations of this agent in a dose of 10 microgram/Kg or over caused a significant increase in blood flow of non-constricted coronary artery. Percent increases in flow were 40 (10 microgram/Kg), 95 (50 microgram/Kg), 145 (100 microgram/Kg), and 195 (250 microgram/Kg). The increases were significantly larger than those caused by the same doses of diltiazem, verapamil, nitroglycerin, isosolbide dinitrate, and papaverine. The durations of the increase in flow were 12 (10 microgram/Kg), 23 (50 microgram/Kg), 28 (100 microgram/Kg), and 46 min (250 microgram/Kg), and they were longer than those caused by diltiazem and verapamil. A slight reduction in left ventricular tension and an increase in aortic blood flow were also observed following the administrations of SG 75 in a dose of over 50 microgram/Kg. A decrease in heart rate was produced with a dose of over 500 microgram/Kg. However, PQ interval of electrocardiogram became shorter. Intravenous administrations of SG 75 in doses of 50 and 150 microgram/Kg caused an increase in blood flow of the constricted coronary artery, while nitroglycerin (10 and 30 microgram/Kg) and nifedipine (1 and 3 microgram/Kg) reduced it. The results indicate that SG 75 is a potent and long-acting coronary vasodilating agent and it causes an increase in blood flow of constricted as well as non-constricted coronary artery.
已对一种新型化学药剂SG 75对麻醉犬冠状动脉血流量的影响进行了研究。静脉注射该药剂,剂量为10微克/千克及以上时,可使未收缩冠状动脉的血流量显著增加。血流量增加的百分比分别为40(10微克/千克)、95(50微克/千克)、145(100微克/千克)和195(250微克/千克)。这些增加量明显大于相同剂量的地尔硫䓬、维拉帕米、硝酸甘油、异山梨醇二硝酸酯和罂粟碱所引起的增加量。血流量增加的持续时间分别为12(10微克/千克)、23(50微克/千克)、28(100微克/千克)和46分钟(250微克/千克),且长于地尔硫䓬和维拉帕米所引起的持续时间。静脉注射剂量超过50微克/千克的SG 75后,还观察到左心室张力略有降低,主动脉血流量增加。剂量超过500微克/千克时会导致心率下降。然而,心电图的PQ间期会缩短。静脉注射剂量为50和150微克/千克的SG 75可使收缩冠状动脉的血流量增加,而硝酸甘油(10和30微克/千克)和硝苯地平(1和3微克/千克)则会使其减少。结果表明,SG 75是一种强效且长效的冠状动脉血管扩张剂,它可使收缩和未收缩冠状动脉的血流量均增加。