血管紧张素I和II对猫股动脉的血管收缩作用。内皮的作用。

Vasoconstrictive effects of angiotensin I and II in cat femoral arteries. Role of endothelium.

Ferrer M, Encabo A, Marín J, Balfagón G

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.

Gen Pharmacol. 1992 Nov;23(6):1171-5. doi: 10.1016/0306-3623(92)90307-6.

Abstract

AI and AII induced concentration-dependent contractions in cat femoral artery segments, the potency of AII being greater than that of AI. 2. The antagonist of AII receptors, saralasin (1 and 10 nM), inhibited the AI and AII responses. 3. Indomethacin (10 microM) and endothelium removal increased the responses to AII, whereas those induced by AI were barely affected. 4. The response induced by AI was reduced by captopril (200 microM). 5. These data suggest: (1) the contractions induced by AII are mediated by AII receptors and endothelial products derived from cyclooxygenase, (2) the response to AI is, in part, produced by its conversion into AII.

摘要

血管紧张素Ⅰ（AI）和血管紧张素Ⅱ（AII）可引起猫股动脉段浓度依赖性收缩，AII的效力大于AI。2. AII受体拮抗剂沙拉新（1和10纳摩尔）可抑制AI和AII的反应。3. 吲哚美辛（10微摩尔）和去除内皮可增强对AII的反应，而AI诱导的反应几乎不受影响。4. 卡托普利（200微摩尔）可降低AI诱导的反应。5. 这些数据表明：（1）AII诱导的收缩由AII受体和环氧化酶衍生的内皮产物介导，（2）对AI的反应部分是由其转化为AII产生的。