Lewis-Barned N J, Ball M J
Department of Medicine, University of Otago, Dunedin.
N Z Med J. 1992 Jul 22;105(938):284-6.
To investigate the effects of simvastatin in patients with heterozygous familial hypercholesterolaemia refractory or intolerant to routine drug therapy.
Eighteen patients were given increasing doses of 10, 20 and 40 mg simvastatin for eight week periods, followed by a control period on their former drug therapy in a prospective, crossover clinical study.
Mean total and low density lipoprotein cholesterol (SEM) were significantly lower on 40 mg simvastatin alone than at the end of the control period (7.3 (0.3) mmol/L vs 10.7 (0.4) and 5.1 (0.3) vs 7.8 (0.5) respectively; p less than 0.01). Apo-B was also significantly lower on 40 mg simvastatin (p less than 0.01).
Simvastatin offers effective cholesterol lowering for patients with drug resistant familial hypercholesterolaemia.
研究辛伐他汀对常规药物治疗无效或不耐受的杂合子家族性高胆固醇血症患者的影响。
在一项前瞻性交叉临床研究中，18名患者接受了为期8周、剂量递增的10毫克、20毫克和40毫克辛伐他汀治疗，随后进入原药物治疗的对照期。
单独使用40毫克辛伐他汀时，平均总胆固醇和低密度脂蛋白胆固醇（标准误）显著低于对照期结束时（分别为7.3（0.3）毫摩尔/升对10.7（0.4），以及5.1（0.3）对7.8（0.5）；p<0.01）。40毫克辛伐他汀治疗时载脂蛋白B也显著降低（p<0.01）。
辛伐他汀对耐药性家族性高胆固醇血症患者有有效的降胆固醇作用。
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