Itasaka Satoshi, Miki Yukio, Tomimoto Hidekazu, Kamei Ichiro, Tsutsui Kazushige
Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Eur J Radiol. 2004 Mar;49(3):193-7. doi: 10.1016/S0720-048X(03)00098-6.
INTRODUCTION/OBJECTIVE: Various pathological changes have been attributed to leukoaraiosis. Some investigators have suggested that increase in interstitial water may partly contribute to leukoaraiosis. We hypothesized that leukoaraiosis may be attenuated by compression to the cerebral hemisphere if interstitial water may partly contribute to leukoaraiosis. We retrospectively reviewed patients with unilateral chronic subdural hematomas (CSDHs) to investigate the difference in appearance of leukoaraiosis between both cerebral hemispheres.
Leukoaraiosis on T2-weighted magnetic resonance (MR) images at the levels of the centrum semiovale and those of the frontal horns of both cerebral hemispheres in five contiguous patients with unilateral CSDHs were scored. The difference in the leukoaraiosis scores on the ipsilateral side and contralateral side of the CSDH was analyzed.
Leukoaraiosis was less prominent on the ipsilateral side of the CSDHs than on the contralateral side of the CSDHs, both at the level of the centrum semiovale (P=0.02) and that of the frontal horns (P=0.03).
Our results support the theories that interstitial water may partly contribute to the appearance of leukoaraiosis on MR images.
引言/目的：多种病理变化被认为与脑白质疏松症有关。一些研究人员认为，间质水分增加可能部分导致了脑白质疏松症。我们推测，如果间质水分可能部分导致脑白质疏松症，那么对大脑半球进行压迫可能会减轻脑白质疏松症。我们回顾性研究了单侧慢性硬膜下血肿（CSDH）患者，以调查双侧大脑半球脑白质疏松症表现的差异。
对连续5例单侧CSDH患者双侧大脑半球半卵圆中心水平和额角水平的T2加权磁共振（MR）图像上的脑白质疏松症进行评分。分析CSDH同侧和对侧脑白质疏松症评分的差异。
在半卵圆中心水平（P=0.02）和额角水平（P=0.03），CSDH同侧的脑白质疏松症均不如对侧明显。
我们的结果支持以下理论，即间质水分可能部分导致MR图像上脑白质疏松症的出现。
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