Kiricuta I C, Willner J, Kölbl O
Klinik und Poliklinik für Strahlentherapie, Universität Würzburg.
Strahlenther Onkol. 1992 Jul;168(7):390-6.
We reviewed the clinical evolution and survival of 671 post mastectomy breast cancer patients. 561 patients underwent a postoperative radiotherapy, whereas 110 did not. After grouping for N0 and N+, the median number of examined axillary lymph nodes in the not irradiated group was for N0 status three and for the N+ status eight axillary lymph nodes. In the latter group the median number of the involved axillary nodes was three. In the post mastectomy irradiated N0 group the median number of examined axillary nodes was five, whereas in the N+ group the corresponding number was seven. The median number of involved nodes was two. The majority of the N0 patients who were not postoperatively irradiated were referred to our clinic with a local recurrence. The study shows that axillary staging of the N0 group was not performed corresponding to the today's accepted oncological norms for the minimum number of axillary nodes to be examined to determine a "true" N0 axillary status. Thus, it was not a surprise to find out, for N0 patients, a dependency of the survival rate on the number of examined axillary nodes. Patients with more than nine examined nodes showed better survival rates than patients with less than five examined nodes (p less than 0.05). The irradiation of the axilla is obligatory in case of incomplete axillary dissection (less than ten negative examined nodes from level I and II and less than 18 nodes for a positive axillary dissection). The irradiation of the axilla is not indicated after a complete axillary clearance.
我们回顾了671例乳腺癌乳房切除术后患者的临床病程及生存情况。561例患者接受了术后放疗,而110例未接受放疗。按N0和N+分组后,未接受放疗组中,N0状态下检查的腋窝淋巴结中位数为3个,N+状态下为8个腋窝淋巴结。在后一组中,受累腋窝淋巴结的中位数为3个。在乳房切除术后接受放疗的N0组中,检查的腋窝淋巴结中位数为5个,而在N+组中相应数字为7个。受累淋巴结的中位数为2个。大多数未接受术后放疗的N0患者因局部复发转诊至我们的诊所。该研究表明,N0组的腋窝分期未按照当今公认的肿瘤学规范进行,即确定“真正”N0腋窝状态所需检查的腋窝淋巴结最小数量。因此,对于N0患者而言,生存率依赖于检查的腋窝淋巴结数量也就不足为奇了。检查淋巴结超过9个的患者比检查淋巴结少于5个的患者生存率更高(p<0.05)。腋窝清扫不彻底(I级和II级检查阴性淋巴结少于10个且腋窝清扫阳性时淋巴结少于18个)的情况下,腋窝放疗是必要的。腋窝彻底清扫后则无需进行腋窝放疗。