[一氧化氮在心血管系统中的活性机制作为相关疾病发病机制治疗的基础]

[Mechanisms of nitric oxide activity in cardiovascular system as a basis of pathogenetic therapy of related diseases].

作者信息

Moĭbenko O O, Sahach V F, Tkachenko M M, Korkushko O V, Bezrukov V V, Kul'chyts'kyĭ O K, Stefanov O V, Solovĭov A I, Mala L T, Frol'kis V V

机构信息

A.A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.

出版信息

Fiziol Zh (1994). 2004;50(1):11-30.

PMID:14965048

Abstract

General characteristics and mechanisms of effects of nitric oxide (NO) and its role in the development of pathology are reviewed. Presented are the data about NO participation in the regulation of circulation and cardiovascular system; NO-dependent mechanism of regulation of cardiovascular reactivity against the background of dysfunction of endothelium; cGMP-independent mechanism of NO effect upon Ca homeostasis and the sensitivity of myofibrils of smooth muscle cells to Ca ions; pharmacological correction of disturbances of NO metabolism and related endothelial dysfunction; role of age changes of the endothelial function in the development of cardiovascular pathology.

摘要

综述了一氧化氮（NO）的一般特性、作用机制及其在病理发展中的作用。介绍了有关NO参与循环和心血管系统调节的数据；在内皮功能障碍背景下NO依赖的心血管反应性调节机制；NO对钙稳态及平滑肌细胞肌原纤维对钙离子敏感性影响的非cGMP依赖机制；NO代谢紊乱及相关内皮功能障碍的药理学纠正；内皮功能年龄变化在心血管病理发展中的作用。