Brecher Mark E, Hay Shauna N
University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA.
Curr Hematol Rep. 2004 Mar;3(2):121-7.
In developed countries, transfusion-transmitted bacterial contamination of platelets is the most common cause of fatalities related to transfusion-transmitted disease. Platelets, to maintain viability and function, must be stored at room temperature (20 degrees-24 degrees C), which creates an excellent growth environment for the proliferation of bacteria. Multiple studies have shown that 1:1000 to 1:2000 platelet units are bacterially contaminated. It is estimated that the risk of a bacterial-related death after a transfusion of a platelet unit ranges from 1:7500 to 1:100,000. The use of bacterial detection to minimize the risk of transfusion-related bacterial sepsis is gaining favor around the world. Implementation of bacterial detection methods would improve safety for patients, result in an extension of the shelf life of platelets, and reduce the outdating of platelets, thus being a cost-saving safety intervention.
在发达国家，血小板的输血传播细菌污染是与输血传播疾病相关的死亡的最常见原因。为维持活力和功能，血小板必须储存在室温（20摄氏度至24摄氏度）下，这为细菌增殖创造了极佳的生长环境。多项研究表明，每1000至2000个血小板单位中就有一个被细菌污染。据估计，输注一个血小板单位后发生与细菌相关死亡的风险在1/7500至1/100,000之间。利用细菌检测来将输血相关细菌性败血症的风险降至最低在全球越来越受到青睐。实施细菌检测方法将提高患者安全性，延长血小板的保质期，并减少血小板过期，因此是一种节省成本的安全干预措施。
