Li Shen-yi, Xu Shi-yuan, Ye Xiao-ping, Xu Rui, Yu Nan, Xu Ping, Hou Jing-li
Department of Anesthesia, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Feb;24(2):223-5.
To study the effects of lidocaine on the balance between cerebral oxygen supply-consumption and on the hemodynamics during anesthesia induction in patients with supratentorial tumor.
Twenty-four patients with supratentorial tumor were randomly divided into lidocaine group (n=12) and control group (n=12). Blood gas analysis and determinations of plasma lactic acid and glucose in the radial artery and internal jugular venous bulb were performed. Oxygen extraction ratio (OER) and blood oxygen content in the artery and internal jugular venous bulb were calculated during anesthesia induction.
OER and difference declined in plasma lactic acid level between the internal jugular venous bulb and the artery, and blood oxygen saturation as well as blood oxygen pressure in the internal jugular venous bulb and the artery increased along with blood oxygen content in the internal jugular venous bulb in both groups during anesthesia induction. Comparison between the groups showed that only the changes in blood oxygen pressure in the internal jugular venous bulb were statistically significant. Changes in the hemodynamics in lidocaine group were less obvious than those in the control group during anesthesia induction.
Lidocaine does not significantly influence cerebral oxygen balance and may effectively inhibit hemodynamic response during anesthesia induction in patients with supratentorial tumor.
研究利多卡因对幕上肿瘤患者麻醉诱导期间脑氧供需平衡及血流动力学的影响。
将24例幕上肿瘤患者随机分为利多卡因组（n = 12）和对照组（n = 12）。进行血气分析，并测定桡动脉和颈内静脉球部血浆乳酸和葡萄糖水平。计算麻醉诱导期间动脉和颈内静脉球部的氧摄取率（OER）及血氧含量。
两组在麻醉诱导期间，颈内静脉球部与动脉间的OER、血浆乳酸水平差值下降，颈内静脉球部和动脉的血氧饱和度、血氧分压随颈内静脉球部血氧含量增加而升高。组间比较显示，仅颈内静脉球部血氧分压的变化具有统计学意义。麻醉诱导期间，利多卡因组血流动力学变化较对照组不明显。
利多卡因对幕上肿瘤患者麻醉诱导期间的脑氧平衡无显著影响，且可有效抑制血流动力学反应。
