Kawarasaki H, Makuuchi M, Ishisone S, Iwanaka T, Hashizume K, Kawasaki S, Matsunami H
Department of Surgery, University of Tokyo, Matsumoto, Japan.
Transplant Proc. 1992 Aug;24(4):1470-2.
Living related liver transplantation was performed in five cases between June 1989 and July 1991 at Shinshu University Hospital. All of the donors were fathers of the patients and blood type was identical in each case. All of them were discharged from the hospital 2 weeks after hepatectomy without any complications. They started to work 2 months after surgery. Four recipients are surviving but one died. Three are enjoying daily life 17 months after LT in case 1, 5 months after LT in case 4, and 4 months after LT in case 5. Case 2 is still in the hospital 14 months after LT. Advantages of LRLT we noted were (1) cases can be performed totally electively and allow full preparation for the family and the transplant team, (2) primary graft nonfunction has not been observed to date, and (3) 38 patients received the chance of liver transplantation in their own country, which under current legislation would not otherwise have been possible. Disadvantages of LRLT were (1) partial hepatectomy was performed in healthy persons, and (2) retransplantation is difficult.
1989年6月至1991年7月间,信州大学医院对5例患者实施了活体亲属肝移植。所有供体均为患者的父亲,且每例供受者血型均相同。所有供体在肝切除术后2周出院,无任何并发症。他们在术后2个月开始工作。4例受者存活,但1例死亡。病例1在肝移植后17个月、病例4在肝移植后5个月、病例5在肝移植后4个月,有3例受者生活正常。病例2在肝移植后14个月仍住院。我们所注意到的活体亲属肝移植的优点有:(1)手术可完全择期进行,能让家属和移植团队做好充分准备;(2)至今未观察到原发性移植物无功能;(3)38例患者在其本国获得了肝移植机会,而根据现行法律,否则这是不可能的。活体亲属肝移植的缺点有:(1)对健康人实施了部分肝切除术;(2)再次移植困难。