[卡介苗对不同类型膀胱损伤壁附着情况的实验研究]
[Experimental study on attachment of bacillus Calmette-Guerin to bladder wall with different types of injury].
作者信息
Ding Guo-qing, Shen Zhou-jun, Chen Zhao-dian
机构信息
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Jan;33(1):65-7. doi: 10.3785/j.issn.1008-9292.2004.01.015.
OBJECTIVE
To investigate whether different types of injury on bladder wall can influence bacillus Calmette-Guerin (BCG) attachment.
METHODS
The bladder mucosa of 24 rabbits were treated by electrocautery,cryocautery and incision on left lateral wall, right lateral wall and posterior wall, respectively. Then radiolabeled BCG ((3)H-BCG) was instilled into bladder. Two hours latter, the injured bladder wall with different methods and non-injured wall (anterior wall of bladder) were surgically removed and digested. The quantity of BCG of each specimen was determined by liquid scintillation counter.
RESULT
The quantity of BCG attachment to bladder wall with different injuries was significantly higher than that of non-injured wall (P<0.001), meanwhile there was no statistically difference among the BCG levels of different injury types (P>0.05).
CONCLUSION
BCG attachment is not influenced by different types of injury on the bladder wall.
目的
探讨膀胱壁不同类型的损伤是否会影响卡介苗（BCG）的附着。
方法
分别对24只兔膀胱黏膜的左侧壁、右侧壁和后壁进行电灼、冷冻和切开处理。然后将放射性标记的卡介苗（³H-BCG）注入膀胱。两小时后，手术切除经不同方法处理的损伤膀胱壁和未损伤壁（膀胱前壁）并进行消化。通过液体闪烁计数器测定每个标本的卡介苗数量。
结果
不同损伤的膀胱壁上卡介苗的附着量显著高于未损伤壁（P<0.001），同时不同损伤类型的卡介苗水平之间无统计学差异（P>0.05）。
结论
膀胱壁不同类型的损伤不影响卡介苗的附着。
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